DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with CD209 Mouse Monoclonal Antibody (C209/1781).
Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CD209 Mouse Monoclonal Antibody (C209/1781).
Formalin-fixed, paraffin-embedded human Small Intestine stained with CD209 Mouse Monoclonal Antibody (C209/1781).
SDS-PAGE Analysis Purified CD209 Mouse Monoclonal Antibody (C209/1781). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of human liver and spleen tissue lysates using CD209 Mouse Monoclonal Antibody (C209/1781).
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