Recombinant IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) Antibody, IgG1, Clone: [rIGHM/2558], Mouse, Monoclonal
Artikelnummer:
NBT-3507-MSM9-P0
Hersteller Artikelnummer:
3507-MSM9-P0
Alternativnummer:
NBT-3507-MSM9-P0-20,NBT-3507-MSM9-P0-100
Hersteller:
NeoBiotechnologies
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FC, IF, IHC, WB
Spezies Reaktivität:
Human
Immunogen:
Heavy chain of human IgM
Alternative Synonym:
AGM1, IGHM, Constant Region of Heavy Chain of IgM, Ig Mu Chain C Region
Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstroms macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Anwendungsbeschreibung:
Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min
Fo
SDS-PAGE Analysis of Purified IgM Mouse Recombinant Monoclonal Antibody (rIGHM/2558). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human Tonsil stained with IgM Mouse Recombinant Monoclonal Antibody (rIGHM/2558).
Formalin-fixed, paraffin-embedded human Tonsil stained with IgM Mouse Recombinant Monoclonal Antibody (rIGHM/2558).
SDS-PAGE Analysis of Purified IGHM Mouse Recombinant Monoclonal Antibody (IrIGHM/2558). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of Human Serum lysate using IgM Mouse Recombinant Monoclonal Antibody (rIGHM/2558)
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