Recombinant fragment (aa 650-750) of human MCM2 protein (exact sequence is proprietary)
Alternative Synonym:
BM28, CCNL1, CDC like 1, cdc19, CDCL1, Cell devision cycle like 1, Cyclin like 1, DNA replication licensing factor MCM2, KIAA0030, Minichromosome maintenance complex component 2, Minichromosome maintenance deficient 2 (mitotin), Minichromosome maintenance protein 2 homolog, Mitotin, Nuclear protein BM28
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal diluti
Formalin-fixed, paraffin-embedded human colon carcinoma stained with MCM2 Mouse Monocl
Formalin-fixed, paraffin-embedded human tonsil stained with MCM2 Mouse Monoclonal Antibody (MCM2/3678). Inset: PBS instead of primary antibody, secondary only control.
Formalin-fixed, paraffin-embedded human colon carcinoma stained with MCM2 Mouse Monoclonal Antibody (MCM2/3678).
Formalin-fixed, paraffin-embedded human colon carcinoma stained with MCM2 Mouse Monoclonal Antibody (MCM2/3678).
SDS-PAGE Analysis of Purified MCM2 Mouse Monoclonal Antibody (MCM2/3678). Confirmation of Purity and Integrity of Antibody.
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