Canine, Feline, Guinea pig, Hamster, Human, Mouse, Rat
Immunogen:
Recombinant full-length human MSH2 protein
Alternative Synonym:
BAT26, COCA1, DNA mismatch repair protein Msh2, FCC1, hMSH2, HNPCC1, LCFS2, MSH2, MutS homolog 2, MutS homolog 2 colon cancer nonpolyposis type 1, MutS protein homolog 2
Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Formalin-fixed, paraffin-embedded human colon stained with MSH2 Recombinant Mouse Monoclonal Antibody (rMSH2/6548).
Formalin-fixed, paraffin-embedded human colon stained with MSH2 Recombinant Mouse Monoclonal Antibody (rMSH2/6548).
Western blot analysis of HCT116 cell lysate using MSH2 Recombinant Mouse Monoclonal Antibody (rMSH2/6548).
SDS-PAGE Analysis Purified MSH2 Recombinant Mouse Monoclonal Antibody (rMSH2/6548). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded dog lymph node stained with MSH2 Recombinant Mouse Monoclonal Antibody (rMSH2/6548).
Western blot analysis of Human Testis, Mouse Testis, Rat Testis, Hamster Testis, Guinea pig Testis, K-562 and HeLa lysates using MSH2 Recombinant Mouse Monoclonal Antibody (rMSH2/6548).
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