bHLHa1, class A basic helix loop helix protein 1, NDR2, NDRF, NeuroD-related factor, NeuroD2, neurogenic basic helix loop helix protein, neurogenic differentiation 2, Neurogenic differentiation factor 2, neuronal differentiation 2
Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes, both of which work together to activate DNA transcription. Class A proteins include the ubiquitously expressed E-box binding factors, namely E2A, ITF-2 and HEB, while class B proteins, such as MyoD, myogenin and Neuro D (A°a2), are transiently expressed and exhibit a much more limited tissue distribution. Working in opposition to these positively acting factors are a specialized group of basic helix-loop-helix(bHLH) transcription factorsthat function as dominant negative regulators and are involved in cell lineage determination and differentiation. Neuro D2 (neurogenic differentiation 2), also known as NDRF, NEUROD2 or bHLHa1, is a 382 amino acid nuclear protein that contains one bHLH domain and functions to induce neurogenic differentiation, playing an important role in the maintenance and determination of cell fate.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Monoclonal Antibody
Anwendungsbeschreibung:
ELISA (For coating, order antibody without BSA), ,Immunoprecipitation (1-2ug per 100-500ug of total protein (1ml of cell lysate)), ,Flow Cytometry (1-2ug/million cells), Immunofluorescence (1-2ug/ml), ,Optimal dilution for a specific application should b
Immunofluorescence Analysis of PFA-fixed HeLa cells stained using NEUROD2 Mouse Mo
Flow cytometric analysis of PFA-fixed HeLa cells. NEUROD2 Mouse Monoclonal Antibody (PCRP-NEUROD2-1G1) followed by goat anti-mouse IgG-CF488 (blue), isotype control (red).
Immunofluorescence Analysis of PFA-fixed HeLa cells stained using NEUROD2 Mouse Monoclonal Antibody (PCRP-NEUROD2-1G1) followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red).
Immunofluorescence Analysis of PFA-fixed HeLa cells stained using NEUROD2 Mouse Monoclonal Antibody (PCRP-NEUROD2-1G1) followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red).
Analysis of Protein Array containing more than 19,000 full-length human proteins using NEUROD2 Mouse Monoclonal Antibody (PCRP-NEUROD2-1G1). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD&apos,s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD&apos,s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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