NTRK2 (Neurotrophic Receptor Tyrosine Kinase 2) Antibody, IgG2c, Clone: [NTRK2/7926], Mouse, Monoclonal

Artikelnummer: NBT-4915-MSM6-P1

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Artikelname:	NTRK2 (Neurotrophic Receptor Tyrosine Kinase 2) Antibody, IgG2c, Clone: [NTRK2/7926], Mouse, Monoclonal
Artikelnummer:	NBT-4915-MSM6-P1
Hersteller Artikelnummer:	4915-MSM6-P1
Alternativnummer:	NBT-4915-MSM6-P1-100
Hersteller:	NeoBiotechnologies
Wirt:	Mouse
Kategorie:	Antikörper
Applikation:	IHC, WB
Spezies Reaktivität:	Guinea pig, Hamster, Human, Mouse, Rat
Immunogen:	Recombinant fragment (around aa250-450) of human NTRK2 protein (exact sequence is proprietary)
Alternative Synonym:	AI848316, BDNF tropomyosine receptor kinase B, BDNF/NT-3 growth factors receptor, Brain derived neurotrophic factor receptor, C030027L06Rik, GP145 TrkB, GP95 TrkB, Neurotrophin receptor tyrosine kinase type 2, Obesity, hyperphagia, and developmental delay, included, RATTRKB1, Tropomyosin related kinase B, Tyrosine receptor kinase B

The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by NTRK2, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue, is equally related to Trk A and Trk B and is a functional receptor for NT-3.

Klonalität:	Monoclonal
Klon-Bezeichnung:	[NTRK2/7926]
Molekulargewicht:	95-145kDa
Isotyp:	IgG2c
NCBI:	4915
UniProt:	Q16620
Formulierung:	200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

	Western blot analysis of Human Brain, Mouse Brain and Rat Brain tissue lysates using NTRK2 Mouse Monoclonal Antibody (NTRK2/7926).
	Western blot analysis of Human Brain, Mouse Brain, Rat Brain, Hamster Brain and Guinea pig Brain tissue lysates using NTRK2 Mouse Monoclonal Antibody (NTRK2/7926).
	Western blot analysis of human brain tissue lysate using NTRK2 Mouse Monoclonal Antibody (NTRK2/7926).
	Formalin-fixed, paraffin-embedded human brain stained with NTRK2 / TRKb Mouse Monoclonal Antibody (NTRK2/7926). Inset: PBS instead of primary antibody, secondary only negative control.
	Formalin-fixed, paraffin-embedded human ovarian cancer stained with NTRK2 / TRKb Mouse Monoclonal Antibody (NTRK2/7926). Inset: PBS instead of primary antibody, secondary only negative control.
	SDS-PAGE Analysis of Purified NTRK2 / TRKb Mouse Monoclonal Antibody (NTRK2/7926). Confirmation of Purity and Integrity of Antibody.

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