Recombinant fragment (around aa100-300) of human NTRK3 protein (exact sequence is proprietary)
Alternative Synonym:
EC 2.7.10.1, ETS related protein neurotrophic receptor tyrosine kinase fusion protein, ETV6 NTRK3 fusion, GP145-TrkC, Neurotrophic tyrosine kinase receptor type 3, Neurotrophin 3 receptor, NT 3 growth factor receptor precursor, TRKC, TrkC tyrosine kinase, Tyrosine kinase receptor C
The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, is mainly expressed in nervous tissue, and is a functional receptor for NT-3. Four forms of Trk C are produced by alternative splicing. Isoform A is full length Trk C, isoform B differs from A between amino acids 529 to 612 and is missing amino acids 613 to 839. Trk C, isoform C is missing amino acids 712 to 725 and isoform D is missing amino acids 402 to 410.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western Blot Analysis of Human Brain and Rat Brain tissue lysates using NTRK3 Mouse Monoclonal Antibody (NTRK3/7140).
SDS-PAGE Analysis of Purified NTRK3 Mouse Monoclonal Antibody (NTRK3/7140). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human breast stained with NTRK3 Mouse Monoclonal Antibody (NTRK3/7140). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
Formalin-fixed, paraffin-embedded human brain stained with NTRK3 Mouse Monoclonal Antibody (NTRK3/7140). Inset: PBS instead of primary antibody, secondary only negative control.
Formalin-fixed, paraffin-embedded human breast stained with NTRK3 Mouse Monoclonal Antibody (NTRK3/7140). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
