Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11, 14)(q13, q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Flow Cytome
Formalin-fixed, paraffin-embedded human Mantle Cell Lymphoma stained with Cyclin D1 Mouse Monoclonal Antibody (CCND1/809).
Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Cyclin D1 Mouse Monoclonal Antibody (CCND1/809).
Flow cytometric analysis of human Cyclin D1 on HeLa cells. Black: cells alone, Green: Isotype Control, Red: PE-labeled Cyclin D1 Mouse Monoclonal Antibody (CCND1/809).
Flow cytometry of human Cyclin D1 on Jurkat cells. Black: cells alone, Grey: Isotype Control, Green: CF488-labeled Cyclin D1 Mouse Monoclonal Antibody (CCND1/809).
Purified Cyclin D1 Mouse Monoclonal Antibody (CCND1/809). Confirmation of Integrity and Purity of Antibody
Flow cytometric analysis of human Cyclin D1 on HeLa cells. Black: cells alone, Green: Isotype Control, Red: PE-labeled Cyclin D1 Monoclonal Antibody (CCND1/809).
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
