HSMT3, Sentrin 2, Small ubiquitin like modifier 2, Small ubiquitin like modifier protein 3, SMT3A, SMT3B, SMT3 homolog 1 (SMT3H1), SMT3 homolog 2 (SMT3H2), SMT3 homolog, SMT3 suppressor of mif two 3 homolog 1, SMT3 suppressor of mif two 3 homolog 2, SMT3 suppressor of mif two 3 homolog 3, Suppressor of mif two 3 homolog 2, Suppressor of mif two 3 homolog 3, Ubiquitin like protein SMT3A, Ubiquitin like protein SMT3B
This MAb reacts with both SUMO-2 and SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimers disease.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Western Blot of HeLa cell lysate using SUMO-2/3 Mouse Monoclonal Antibody (SM23/496)
Flow Cytometric Analysis of paraformaldehyde-fixed He
Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with SUMO-2/3 Mouse Monoclonal Antibody (SM23/496)
Western Blot of HeLa cell lysate using SUMO-2/3 Mouse Monoclonal Antibody (SM23/496)
Flow Cytometric Analysis of paraformaldehyde-fixed HepG2 cells using SUMO-2/3 Mouse Monoclonal Antibody (SM23/496) followed by goat anti- Mouse- IgG-CF488 (Blue), Isotype Control (Red).
Immunofluorescence staining of paraformaldehyde-fixed MCF-7 cells with SUMO-2/3 Mouse Monoclonal Antibody (SM23/496) followed by goat anti-Mouse IgG-CF488 (Green). Membrane are labeled with Phalloidin (Red).
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