TNF-alpha (Tumor Necrosis Factor alpha) Antibody, IgM, Clone: [TNFA/1172], Mouse, Monoclonal

Artikelnummer: NBT-7124-MSM12-P1

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Artikelname:	TNF-alpha (Tumor Necrosis Factor alpha) Antibody, IgM, Clone: [TNFA/1172], Mouse, Monoclonal
Artikelnummer:	NBT-7124-MSM12-P1
Hersteller Artikelnummer:	7124-MSM12-P1
Alternativnummer:	NBT-7124-MSM12-P1-100
Hersteller:	NeoBiotechnologies
Wirt:	Mouse
Kategorie:	Antikörper
Applikation:	FC, IF, IHC
Spezies Reaktivität:	Human, Rat
Immunogen:	Recombinant full-length human TNF-alpha protein
Alternative Synonym:	APC1, Cachectin, Differentiation inducing factor (DIF), Macrophage cytotoxic factor (MCF), Necrosin, TNF alpha, TNF Macrophage Derived, TNF Monocyte Derived, TNF Superfamily Member 2, TNFA, TNFSF2, Tumor necrosis factor ligand superfamily member 2, Tumor Necrosis Factor Precursor

This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule, or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

Klonalität:	Monoclonal
Klon-Bezeichnung:	[TNFA/1172]
Molekulargewicht:	17kDa
Isotyp:	IgM
NCBI:	7124
UniProt:	P01375
Formulierung:	200ug/ml of Ab Purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

	Formalin-fixed, paraffin-embedded human Pancreas stained with TNF alpha Mouse Monoclonal Antibody (TNFA/1172).
	Formalin-fixed, paraffin-embedded human Erdheim-Chester disease (also known as polyostotic sclerosing histiocytosis) stained with TNF alpha Mouse Monoclonal Antibody (TNFA/1172).
	Formalin-fixed, paraffin-embedded Rat Stomach stained with TNF alpha Mouse Monoclonal Antibody (TNFA/1172).
	Formalin-fixed, paraffin-embedded Rat Pancreas stained with TNF alpha Mouse Monoclonal Antibody (TNFA/1172).
	Immunofluorescence Analysis of PFA-fixed HePG2 cells labeling TNFalpha with TNF alpha Mouse Monoclonal Antibody (TNFA/1172) followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Redot.
	Flow Cytometric Analysis of PFA-fixed HePG2 cells using TNF alpha Mouse Monoclonal Antibody (TNFA/1172) followed by Goat anti- Mouse- IgG-CF488 (Blue), Isotype Control (Red).

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