Recombinant fragment (around aa 247-382) of human ZAP70 protein (exact sequence is proprietary)
Alternative Synonym:
Selective T cell defect, SRK, STD, Syk-related tyrosine kinase, Tyrosine-protein kinase ZAP-70,TZK, Zeta chain associated protein kinase 70kDa
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody Type:
Recombinant Monoclonal Antibody
Anwendungsbeschreibung:
ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA), Western Blot (1-2ug/ml),,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA,
Formalin-f
Formalin-fixed, paraffin-embedded human lymphoma stained with ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70/3921R).
Formalin-fixed, paraffin-embedded human lymphoma stained with ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70/3921R).
Formalin-fixed, paraffin-embedded human tonsil stained with ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70/3921R).
SDS-PAGE Analysis of Purified ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70/3921R). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of Jurkat cell lysate using ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70/3921R).
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
