A recombinant fragment of human B7-H4 protein (exact sequence is proprietary)
Alternative Synonym:
B7 family member, H4, B7 homolog 4, B7 superfamily member 1, B7-H4, B7S1, Immune costimulatory protein B7-H4, T-cell costimulatory molecule B7x, V-set domain-containing T-cell activation inhibitor 1, VCTN1
T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Immunofluorescence staining of SKBR-3 cells usingB7-H4 Mouse Monoclonal Antibody (B7H4/1788),
Flow Cytometric Analysis of SKBR-3 cells using B7-H4 Mouse Monoclonal Antibody (B7H4/1788) followed by goat anti-Mouse IgG-CF488 (Blue), Isotype Control (Red).
Immunofluorescence staining of SKBR-3 cells usingB7-H4 Mouse Monoclonal Antibody (B7H4/1788), followed by goat anti-mouse IgG-CF488 (green). Nuclear counterstain is Reddot.
Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with B7-H4 Mouse Monoclonal Antibody (B7H4/1788).
SDS-PAGE Analysis Purified B7-H4 Mouse Monoclonal Antibody (B7H4/1788). Confirmation of Purity and Integrity of Antibody.
Western Blot of HCT116 cell lysates using B7-H4 Mouse Monoclonal Antibody (B7H4/1788).
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