A portion of amino acids 258-287 from the human protein was used as the immunogen for this CHK1 antibody.
Checkpoint kinase 1, commonly referred to as CHK1 is an serine/threonine-specific protein kinase that in humans, is encoded by the CHEK1 gene. CHK1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle.
The stated application concentrations are suggested starting amounts. Titration of the CHK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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