A portion of amino acids 288-317 from the human protein was used as the immunogen for this p73 antibody.
TP73 is tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each others promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors.
