This GLI2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1287-1321 amino acids from the C-terminal region of human GLI2.
Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5-GAACCACCCA-3 which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Is involved in the smoothened (SHH) signaling pathway.
Titration of the GLI2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. GLI-2 exists as five alternatively spliced isoforms of 133 kDa (isoform 1), 132 (2), 88 (3), 86 (4) and 168 kDa (isoform 5).
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