This KDM6A antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 797-832 amino acids from the Central region of human KDM6A.
Histone demethylase that specifically demethylates Lys- 27 of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 Lys-27. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of Lys-27 of histone H3 is concomitant with methylation of Lys-4 of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.
