This Shh antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 368-401 amino acids from the C-terminal region of human Sonic hedgehog.
Sonic hedgehog is an intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity).
Titration of the Shh antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. 1. The 45 kDa precursor protein autocleaves into 27 kDa amino and 19 kDa carboxy fragments.
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