A portion of amino acids 260-289 from the human protein was used as the immunogen for the Sciellin antibody.
The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined.
The stated application concentrations are suggested starting points. Titration of the Sciellin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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