A portion of amino acids 102-135 from the human protein was used as the immunogen for the AKR1B1 antibody.
AKR1B1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol.
The stated application concentrations are suggested starting points. Titration of the AKR1B1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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