A portion of amino acids 214-242 from the human protein was used as the immunogen for the TOX-3 antibody.
TOX-3 contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer.
The stated application concentrations are suggested starting points. Titration of the TOX-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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