PD1 Antibody / PDCD1, Clone: [RMP1-14], Rat, Monoclonal
Artikelnummer:
NSJ-V8347SAF-100UG
Hersteller Artikelnummer:
V8347SAF-100UG
Alternativnummer:
NSJ-V8347SAF-100UG
Hersteller:
NSJ Bioreagents
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
ELISA, FACS, IF, NeA
Spezies Reaktivität:
Mouse
Immunogen:
PDCD1 transfected BHK cells were used as the immunogen for the PD1 antibody.
PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally, Pdcd1 mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells).
