CD134 Antibody / OX40, Clone: [OX-86], Rat, Monoclonal
Artikelnummer:
NSJ-V8349-100UG
Hersteller Artikelnummer:
V8349-100UG
Alternativnummer:
NSJ-V8349-100UG
Hersteller:
NSJ Bioreagents
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
FACS, IF
Spezies Reaktivität:
Mouse
Immunogen:
Purified recombinant mouse OX40 antigen was used as the immunogen for the CD134 antibody.
CD134 is a type I integral membrane protein. This receptor is expressed on activated CD4+and CD8+T cells and B cells. The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. CD134 is involved in coordinating CD4 T cell selection, migration and cytokine differentiation in T helper (Th)1 and Th2 cells. CD134 is also involved in the stimulation of T cells, T dependent humoral response and generation of optimal CD4+ T cell responses in vivo and in vitro. CD134 is expressed on activated CD4+ T lymphocytes, and its ligand, CD134L, is found preferentially on activated B cells. Engagement of CD134 with its ligand, CD134L, delivers a strong costimulatory signal to effector T cells.
