Mouse CTL clone V4 was used as the immunogen for the CD4 antibody.
CD4 is a member of the Ig superfamily, primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC class II and associating with the protein tyrosine kinase, lck. CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.This antibody blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.
ELISA (order BSA-free format for coating & Azide),Neutralization Studies (order BSA/azide-free format),Flow cytometry: 1-2ug/10 6 cells in 0.1ml,Immunofluorescence: 1-2ug/ml
Anwendungsbeschreibung:
Optimal dilution of the CD4 antibody should be determined by the researcher.
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