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Recombinant Thyroglobulin Antibody, Clone: [rTGB/4744], Mouse, Monoclonal

Recombinant Thyroglobulin Antibody, Clone: [rTGB/4744], Mouse, Monoclonal

Artikelnummer: NSJ-V8717SAF-100UG

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Artikelname:	Recombinant Thyroglobulin Antibody, Clone: [rTGB/4744], Mouse, Monoclonal
Artikelnummer:	NSJ-V8717SAF-100UG
Hersteller Artikelnummer:	V8717SAF-100UG
Alternativnummer:	NSJ-V8717SAF-100UG
Hersteller:	NSJ Bioreagents
Wirt:	Mouse
Kategorie:	Antikörper
Applikation:	FACS, IHC-P
Spezies Reaktivität:	Human
Immunogen:	Human thyroid follicular cells were used as the immunogen for the recombinant Thyroglobulin antibody.

mAb rTGB/4744 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by mAb 6E1. Thyroglobulin is a 660kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.

Klonalität:	Monoclonal
Klon-Bezeichnung:	[rTGB/4744]
UniProt:	P01266
Reinheit:	Protein G affinity chromatography
Formulierung:	1 mg/ml in 1X PBS, BSA free, sodium azide free
Antibody Type:	Primary Antibody

Application Verdünnung:	Flow cytometry: 0.5-1ug/million cells,Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
Anwendungsbeschreibung:	Optimal dilution of the recombinant Thyroglobulin antibody should be determined by the researcher.

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