WM3912 is a metastatic human melanoma cell line established from a neck metastatic site of a patient. This cell line thaws poorly and contains lots of spontaneous senescent cells. This cell line features the N581Y mutation at codon 581 in the BRAF gene. The N581Y mutation results in an amino acid substitution at position 581 in the BRAF, from an asparagine (N) to a tyrosine (Y). This cell line also expresses L213F mutation in CDK4 gene which results in an amino acid substitution at codon 213 in the CDK4 from leucine (L) to phenylalanine (F). WM3912 cells produce xenograft tumors when injected into immunocompromised mice.
Konzentration:
1.0 million cells/mL (Count By Hemocytometer)
Puffer:
None
Quelle:
Human
Formulierung:
Frozen Cell Suspension
Anwendungsbeschreibung:
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Human melanoma tumor cells with known gene mutations, disease stage, STR, and RPPA profiling
Established WM3912 viable cell growth in culture using appropriate Tumor Specialized Media with 2%FBS.
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