Hex is an enolase inhibitor and antimalarial agent with Ki values of 74.4 nM and 269.4 nM against ENO2 and ENO1, respectively, its IC50 values against NfENO and TbENO are 0.14 µM and 2.1 µM, respectively. Hex exhibits antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites, and Plasmodium berghei ANKA strain, and also shows certain antitumor effects against intracranial tumors.
Molekulargewicht:
195.11
CAS Nummer:
[2004714-32-1]
Formel:
C5H10NO5P
Target-Kategorie:
Glucokinase|||Parasite
T39419
T39419
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