DBCO-PEG4-VC-PAB-MMAE is a drug-linker complex consisting of an ADC linker (DBCO-PEG4-VC-PAB) and the tubulin polymerization inhibitor MMAE. It is a key building block utilized for the synthesis of antibody-drug conjugates (ADCs). MMAE, a synthetic derivative of dolastatin 10, functions as a potent mitotic inhibitor by blocking tubulin polymerization. The reagent features a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules via click chemistry. The VC-PAB (Valine-Citrulline-p-aminobenzylcarbamate) moiety is a Cathepsin B-cleavable linker, ensuring site-specific drug release within the lysosomal environment of target cells.
Molekulargewicht:
1658.06
CAS Nummer:
[2129164-91-4]
Formel:
C88H128N12O19
Target-Kategorie:
Drug-Linker Conjugates for ADC
T39576
T39576
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