LY487379 is a selective mGluR2 positive allosteric modulator (PAM). It potently enhances glutamate-stimulated signaling, with EC50 values of 1.7 µM for mGlu2 and >10 µM for mGlu3 receptors, demonstrating high subtype selectivity. In behavioral models, LY487379 has been shown to promote cognitive flexibility and facilitate behavioral inhibition. It serves as a valuable tool for researching the therapeutic potential of mGluR2 modulation in schizophrenia and related cognitive impairments.
Molekulargewicht:
452.45
Reinheit:
99.94%
CAS Nummer:
[353231-17-1]
Formel:
C21H19F3N2O4S
Target-Kategorie:
GluR
T62756
T62756
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