CYP19A1/CYP11B2-IN-1 is a potent dual inhibitor of aromatase (CYP19A1) and aldosterone synthase (CYP11B2), with IC50 values of 2.3 nM and 29 nM, respectively. CYP19A1/CYP11B2-IN-1 inhibits breast cancer cell proliferation and induces apoptosis (IC50 of 0.26 0.03 µM against MCF-7 cells). CYP19A1/CYP11B2-IN-1 downregulates the PI3K/Akt/mTOR signaling pathway by inhibiting mTOR phosphorylation.
Molekulargewicht:
213.24
Reinheit:
99.71%
CAS Nummer:
[183500-36-9]
Formel:
C12H11N3O
Target-Kategorie:
Cytochromes P450
T86150
T86150
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