HEI3090 is an activator of the P2X7R receptor. This compound enhances the production of IL-18 by stimulating dendritic cells that express P2X7R, which in turn promotes the production of IFN-gamma by natural killer cells and CD4T cells within tumors, triggering a sustained anti-tumor response. Additionally, HEI3090 can be used to improve the efficacy of alphaPD-1 therapy in non-small cell lung cancer (NSCLC).
Molekulargewicht:
441.7
CAS Nummer:
[2377167-56-9]
Formel:
C18H15Cl3N4O3
Target-Kategorie:
Interleukin|||IFNAR|||P2X Receptor
T89862
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