SPI-001 is a selective inhibitor of PPM1D (IC50=0.48 µM) that exhibits anticancer activity. The compound inhibits the phosphatase activity of PPM1D in human breast cancer cells overexpressing PPM1D and enhances the phosphorylation of p53. Additionally, SPI-001 suppresses cell proliferation by inducing apoptosis.
Molekulargewicht:
540.97
CAS Nummer:
[1220996-46-2]
Formel:
C30H60O4Si2
Target-Kategorie:
Phosphatase|||Apoptosis|||MDM-2/p53
T89868
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