SKI-178, CAS [[1259484-97-3]]
Artikelnummer:
TGM-T9014
- Bilder (1)
| Artikelname: | SKI-178, CAS [[1259484-97-3]] |
| Artikelnummer: | TGM-T9014 |
| Hersteller Artikelnummer: | T9014 |
| Alternativnummer: | TGM-T9014-1MLX10MM(INDMSO),TGM-T9014-2MG,TGM-T9014-5MG,TGM-T9014-10MG,TGM-T9014-25MG,TGM-T9014-50MG,TGM-T9014-100MG,TGM-T9014-500MG |
| Hersteller: | TargetMol |
| Kategorie: | Biochemikalien |
| SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 µM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1. |
| Molekulargewicht: | 394.42 |
| Reinheit: | 97.09% |
| CAS Nummer: | [1259484-97-3] |
| Formel: | C21H22N4O4 |
| Target-Kategorie: | S1P Receptor|||Apoptosis |
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T9014 |
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