Anti-GPR44/PTGDR2/CD294 Antibody is a humanized monoclonal antibody expressed in CHO cells targeting the GPCR GPR44 (CRTH2/PTGDR2). Featuring a huIgG1 heavy chain and a hukappa light chain, it binds specifically to the extracellular domain of GPR44, blocking the binding of its ligand PGD2. This antagonism inhibits PGD2-induced Gi protein-coupled signaling, restoring intracellular cAMP levels and reducing calcium mobilization, thereby inhibiting the chemotaxis and activation of Th2 cells, eosinophils, and basophils.
Target-Kategorie:
GPCR
T9901A-1353
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