MEDI-570 is a humanized IgG1 monoclonal antibody produced in CHO cells, targeting the inducible T-cell costimulator (ICOS/CD278). Functioning as a potent agonist, it binds with high affinity to the ICOS receptor, mimicking and amplifying the costimulatory signal of its natural ligand, ICOS-L. This agonistic activity promotes the activation, proliferation, survival, and cytokine production of T cells, including effector T cells and T follicular helper (Tfh) cells. It is developed as a cancer immunotherapeutic agent designed to combat tumors by enhancing T-cell function.
CAS Nummer:
[2179209-59-5]
Target-Kategorie:
Others
T9901A-1359
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