AFM24 is a bispecific antibody with a TandAb structure expressed in CHO cells, simultaneously targeting the Epidermal Growth Factor Receptor (EGFR) and FcgammaRIIIA (CD16A). It consists of a huIgG1-scFv heavy chain and a lambda light chain, with a predicted molecular weight of 196.34 kDa. As a novel innate immune cell engager, AFM24 binds with high affinity to CD16A on NK cells and macrophages, directing these effector cells to eliminate EGFR-positive tumor cells. Its mechanism primarily leverages enhanced antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) to overcome limitations of conventional anti-EGFR therapies.
Reinheit:
95.00%
Target-Kategorie:
EGFR|||Immunology/Inflammation related
T9901A-513
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