Avexitide (Exendin-3(9-39)amide) is a specific, competitive GLP-1 receptor antagonist (Ki = 0.36 nM). Avexitide binds to the GLP-1 receptor (GLP-1R) with high affinity (Kd = 0.42 nM), blocking the interaction between endogenous GLP-1 and the receptor, thereby counteracting the effects of excessive GLP-1 secretion. Avexitide is being studied for post-bariatric hypoglycemia (PBH) and congenital hyperinsulinism.
Molekulargewicht:
3369.76
Reinheit:
98.00%
CAS Nummer:
[133514-43-9]
Formel:
C149H234N40O47S
Target-Kategorie:
Glucagon Receptor
TP2100
TP2100
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