PCGF2 (MEL18, RNF110, ZNF144, Polycomb Group RING Finger Protein 2, DNA-binding Protein Mel-18, RING Finger Protein 110, Zinc Finger Protein 144, MGC10545) (MaxLight 490), Clone: [4D6], Mouse, Monoclonal
PCGF2 (MEL18, RNF110, ZNF144, Polycomb Group RING Finger Protein 2, DNA-binding Protein Mel-18, RING Finger Protein 110, Zinc Finger Protein 144, MGC10545) (MaxLight 490), Clone: [4D6], Mouse, Monoclonal
PCGF2 (MEL18, RNF110, ZNF144, Polycomb Group RING Finger Protein 2, DNA-binding Protein Mel-18, RING Finger Protein 110, Zinc Finger Protein 144, MGC10545) (MaxLight 490), Clone: [4D6], Mouse, Monoclonal
Artikelnummer:
USB-130987-ML490
Hersteller Artikelnummer:
130987-ML490
Alternativnummer:
USB-130987-ML490-100
Hersteller:
US Biological
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FLISA, WB
Immunogen:
Partial recombinant corresponding to aa236-295 from human PCGF2 (AAH04858) with GST tag. MW of the GST tag alone is 26kD.
MaxLight(TM)490 is a new Blue-Green photostable dye conjugate comparable to DyLight(TM)488, Alexa Fluor(TM)488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm), Emission (515nm), Extinction Coefficient 73,000. The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. Applications: Suitable for use in Western Blot and FLISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: LTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPA* Storage and Stability: Store product at 4C in the dark. DO NOT FREEZE! Stable at 4C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight(TM)490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.
