CD33 is a member of the SIGLEC (Sialic Acid-Binding Ig-Like Lectin) family of receptors, and the gene comprises seven coding exons. Exon 2 encodes the canonical IgV domain, exon 4 encodes the IgC structural domain, and exons 6 and 7 encode cytosolic ITIMs (Immunotyrosine Inhibitory Motifs). CD33 acts as a cell surface antigen which is expressed on normal myeloid cells and CD34+ blasts in AML (Acute Myeloid Leukemia). The antigen serves as a target of GO (Gemtuzumab/Ozogamicin), which exerts anti-leukemic effects in refractory AML.
Figure-1: Cell Surface flow analysis of hCD33 in PBMC using 0.5 µg/10 6 cells. Green represents isotype control (ABEOMICS), red represents anti-hCD33 antibody (10-4138). Goat anti-mouse PE conjugated secondary antibody (ABEOMICS) was used.
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