Monoclonal Antibody to CD20 (Clone: ABM46C7) FITC Conjugated
Biozol Catalog Number:
ABI-10-4162-F
Supplier Catalog Number:
10-4162-F
Alternative Catalog Number:
ABI-10-4162-F-100UG
Manufacturer:
Abeomics
Host:
Mouse
Category:
Antikörper
Application:
FACS
Species Reactivity:
Human
Immunogen:
A partial length recombinant protein corresponding to extra cellular domain of CD20 was used as the immunogen for this antibody.
Conjugation:
FITC
Alternative Names:
MS4A1||CD20
CD20 is clinically validated as an immunotherapy target for B-cell lymphomas and autoimmune diseases. CD20 consists of large, intracellular, amino- and carboxyterminal portions connected by 4 membrane-spanning domains. Its high expression on malignant B cells and its reported lack of shedding from the surfacemake CD20 an ideal target for antibody-mediated killing. Anti-CD20 antibodies are believed to mediate the therapeutic effect by activation of complement-dependent cytotoxicity (CDC) and largely by antibody-dependent cellular cytotoxicity exerted by recruitment of innate immune effector cells expressing the Fcgamma receptor IIIa.
Fig-1: Cell surface flow analysis of hCD20 in PBMC using 0.5 µg/10 6 cells. Green represents isotype control (ABEOMICS), red represents FITC conjugated anti-hCD20 antibody (10-4162F).
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