Phospho-Stat1 (Ser727) (Clone: C6) rabbit mAb PE conjugate, Clone: [Stat1S727-C6], Rabbit, Monoclonal
Biozol Catalog Number:
ABI-12-4128
Supplier Catalog Number:
12-4128
Alternative Catalog Number:
ABI-12-4128-100TESTS
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
FACS
Species Reactivity:
Human
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser727 of human phospho Stat1
Conjugation:
PE
Alternative Names:
Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84
Stat1 mediates the cellular response to IFN alpha, IFNB, and IFNg for the regulation of cell growth and the defense against viral and immune challenges. The Jak-Stat pathway plays a central role in the IFNg response, where Stat1 phosphorylation on Tyr701 causes homodimerization through its SH2 domain, translocation to the nucleus, and binding to gamma-activated sequence (GAS) elements. Early in the activation sequence, Stat1 is also phosphorylated at Ser727 through a mechanism involving PI3 kinase and Akt. Stat1 has been found to correlate with increased resistance to chemotherapeutic drugs. However, Stat1 activation of the immune system helps suppress tumor growth, and multiple melanomas and squamous-cell carcinomas have been known to downregulate Stat1 expression to evade immune surveillance.
Clonality:
Monoclonal
Clone Designation:
[Stat1S727-C6]
Form:
Conjugated
Application Dilute:
For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
* VAT and and shipping costs not included. Errors and price changes excepted
