Phospho-Stat4 (Tyr693) (Clone: F6) rabbit mAb PE conjugate, Clone: [Stat4Y693-F6], Rabbit, Monoclonal
Biozol Catalog Number:
ABI-12-4233
Supplier Catalog Number:
12-4233
Alternative Catalog Number:
ABI-12-4233-100TESTS
Manufacturer:
Abeomics
Host:
Rabbit
Category:
Antikörper
Application:
FACS
Species Reactivity:
Human, Mouse
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr693 of human phospho Stat4
Conjugation:
PE
Alternative Names:
Signal transducer and activator of transcription 4
In response to IL-12 binding, the IL-12 receptor activates the Jak kinases, which phosphorylate tyrosine residues of IL-12RB2. These phosphorylated receptors recruit Stat4 through its SH2 domain, whereupon Stat4 is phosphorylated at Tyr693 in its C-terminal transactivation domain. Phosphorylation promotes Stat4 homodimerization and translocation to the nucleus, where it promotes gene transcription. The N-terminal domain of Stat4 appears to be required for maximal stabilization and for the binding of Stat4 dimers to lower-affinity DNA binding sites. Stat4-deficient mice have demonstrated that this gene is required to both promote Th1 development and inhibit Th2 differentiation due to disabling IL-12 receptor-mediated responses.
Clonality:
Monoclonal
Clone Designation:
[Stat4Y693-F6]
Form:
Conjugated
Application Dilute:
For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
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