Human donors targeting the post-fusion RSV F protein using human hybridoma technology
Alternative Names:
RSV, Orthopneumovirus
Reactivity Species : Respiratory Syncytial-Virus Expression Host : HEK-293 Endotoxin Level : 1.0 EU/mg as determined by the LAL method Specificity : RSV-17E10 activity is directed against antigenic site IV of the RSV and hMPV fusion (F) proteins and binds to pre- and post-fusion F proteins of RSV A strain A2 and RSV B strain 18537. Antibody RSV-17E10 is also capable of neutralizing RSV A2, RSV Long viruses (subgroup A), RSV 18537 B, and RSV WV/401R viruses (subgroup B). Competition-binding assay shows that RSV-17E10 targets antigenic site IV. The mode of action is independent of R429. RSV-17E10 is cross-reactive with hMPV F at antigenic site IV and neutralizes hMPV better than RSV. Cross-neutralization of RSV and hMPV is associated with recognition of the G430 and I432 residues, which are shared between RSV and hMPV F proteins. RSV-17E10 binds at a unique ~56 tilt, which may be a determinant of cross-reactivity with hMPV F.
Clonality:
Monoclonal
Clone Designation:
[RSV-17E10]
Purity:
>=95% monomer by analytical SEC
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