Human donors targeting the post-fusion RSV F protein using human hybridoma technology.
Alternative Names:
RSV, Orthopneumovirus.
Reactivity Species : Respiratory Syncytial-Virus Expression Host : HEK-293 Endotoxin Level : 1.0 EU/mg as determined by the LAL method. Specificity : RSV-3M3 activity is directed against antigenic site IV of the RSV fusion (F) protein and binds to pre- and post-fusion F proteins of RSV A strain A2 and RSV B strain 18537. Clone RSV-3M3 is potent at neutralizing RSV A2, RSV Long viruses (subgroup A), RSV 18537 B, and RSV WV/401R viruses (subgroup B). Competition-binding assay shows that RSV-3M3 targets antigenic site IV. Mutagenesis experiments have revealed RSV-3M3 requires arginine residue R429 for binding and neutralization. EM reconstruction shows that RSV-3M3 binds close to a 0 tilt. RSV-3M3 does not neutralize hMPV.
Clonality:
Monoclonal
Clone Designation:
[RSV-3M3]
Purity:
>=95% monomer by analytical SEC
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