HENV-117 was isolated from circulating B cells of an individual exposed to equine HeV vaccine.
Reactivity Species : Henipavirus<_Virus Expression Host : HEK-293 Endotoxin Level : 1.0 EU/mg as determined by the LAL method Specificity: HENV-117 activity is directed against the receptor-binding domain of receptor binding protein (RBP). HENV-117, has shown to neutralizes HeV, NiVM, or NiVB with exceptional potency according to the literature and HENV-117 maps to the receptor-binding domain of HeV-RBP and displays a receptor-blocking phenotype. Binding decreases substantially in the presence of ephrin-B2, indicating HENV-117 neutralizes by blocking binding of virus to host cells. nsEM mapping shows that HENV-117 mimics ephrin-B2 binding.
Clonality:
Monoclonal
Clone Designation:
[HENV-117]
Purity:
>=95% monomer by analytical SEC
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