The poly-Glycine-Serine (G4S) linker is a type of flexible, unstructured synthetic peptide linker sequence often leveraged to connect antibody fragments (scFvs) and fusion proteins . The linker itself consists of a core pentapeptide sequence, Gly-Gly-Gly-Gly-Ser, that is repeated and commonly found as either a 15-mer (G4S)3 or 20-mer (G4S)4 within scFv-based CARs and scFv fragments. The linker sequence length plays a role in controlling scFv stability and the noncovalent association between the VH and VL domains.Anti-(G4S)4 antibody(BM1049) can binds to linkers with more than one repeat of GGGGS peptide.
Clonality:
Monoclonal
Clone Designation:
[BM1049]
Purity:
Purified from cell culture supernatant by affinity chromatography
Target:
G4S linker
Antibody Type:
Secondary Antibody
Application Dilute:
FACS 1:100 ELISA 1:5000-10000
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