The poly-Glycine-Serine (G4S) linker is a type of flexible, unstructured synthetic peptide linker sequence often leveraged to connect antibody fragments (scFvs) and fusion proteins . The linker itself consists of a core pentapeptide sequence, Gly-Gly-Gly-Gly-Ser, that is repeated and commonly found as either a 15-mer (G4S)3 or 20-mer (G4S)4 within scFv-based CARs and scFv fragments. The linker sequence length plays a role in controlling scFv stability and the noncovalent association between the VH and VL domains.
Clonality:
Monoclonal
Clone Designation:
[12H7]
Buffer:
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.
Purity:
Purified from cell culture supernatant by affinity chromatography
Target:
G4S linker
Antibody Type:
Recombinant Antibody
Application Dilute:
ELISA 1/5000-10000
* VAT and and shipping costs not included. Errors and price changes excepted
