This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Clonality:
Monoclonal
Clone Designation:
[DM79]
Purity:
Purified from cell culture supernatant by affinity chromatography
Target:
GITR
Antibody Type:
Recombinant Antibody
Application Dilute:
ELISA 1/5000-10000,FACS 1/100
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