Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor, IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
Clonality:
Monoclonal
Clone Designation:
[DM126]
Purity:
Purified from cell culture supernatant by affinity chromatography
Target:
IL17RA
Antibody Type:
Recombinant Antibody
Application Dilute:
ELISA 1/5000-10000,FACS 1/100
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