The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Clonality:
Monoclonal
Clone Designation:
[DM148]
Purity:
Purified from cell culture supernatant by affinity chromatography
Target:
IL2RA
Antibody Type:
Recombinant Antibody
Application Dilute:
ELISA 1/5000-10000,FACS 1/100
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