Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the innernuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact withchromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role innuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal developmentof peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required forosteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping tomaintain the volume and strength of skeletal muscle and bone Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and prematuresenescence.
Clonality:
Monoclonal
Clone Designation:
[5D12-C6-E9]
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